Phosphorylated JAK1 (p-Y-JAK1) phosphorylates the STAT proteins STAT1 (Tian et al. 1994, Tian et al. 1996, Shimoda et al. 1997, also inferred from mouse homologs), STAT3 (Tian et al. 1994, Tian et al. 1996, Shimoda et al. 1997, Ward et al. 1999, Marino and Roguin 2008, Kumar et al. 2014, also inferred from mouse homologs), and STAT5 (Tian et al. 1994, Tian et al. 1996, Shimoda et al. 1997, also inferred from mouse homologs) at the cytosolic domain of CSF3R (G-CSFR). Phosphorylated JAK2 acts redundantly with p-Y-JAK1 to phosphorylate STAT proteins (Kumar et al. 2014, also inferred from mouse homologs).
Tian, SS, Seidel, HM, Rosen, J, Stein, RB, Lamb, P
Nagata, S, Ihle, JN, Murakami, H, Stark, GR, Rogers, NC, Feng, J, Shimoda, K, Kerr, IM, Watling, D
Ward, AC, Fraser, FW, Ahmed, N, McCulloch, DR, Riley, C, Kumar, J
Schelen, AM, Smith, L, Ward, AC, Touw, IP, Hermans, MH, Antonissen, C, van Aesch, YM
Tian, SS, Rosen, J, Tapley, P, Stein, RB, Sincich, C, Lamb, P
Marino, VJ, Roguin, LP
protein tyrosine kinase activity of CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane]
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