Reactome | p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2

p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2

Stable Identifier

R-HSA-9674567

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2

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Phosphorylated JAK1 (p-Y-JAK1) phosphorylates the STAT proteins STAT1 (Tian et al. 1994, Tian et al. 1996, Shimoda et al. 1997, also inferred from mouse homologs), STAT3 (Tian et al. 1994, Tian et al. 1996, Shimoda et al. 1997, Ward et al. 1999, Marino and Roguin 2008, Kumar et al. 2014, also inferred from mouse homologs), and STAT5 (Tian et al. 1994, Tian et al. 1996, Shimoda et al. 1997, also inferred from mouse homologs) at the cytosolic domain of CSF3R (G-CSFR). Phosphorylated JAK2 acts redundantly with p-Y-JAK1 to phosphorylate STAT proteins (Kumar et al. 2014, also inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
7521688	Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor Tian, SS, Lamb, P, Seidel, HM, Stein, RB, Rosen, J	Blood	1994
9226159	Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor Shimoda, K, Feng, J, Murakami, H, Nagata, S, Watling, D, Rogers, NC, Stark, GR, Kerr, IM, Ihle, JN	Blood	1997
24220695	Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer Kumar, J, Fraser, FW, Riley, C, Ahmed, N, McCulloch, DR, Ward, AC	Br. J. Cancer	2014
9864153	Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration Ward, AC, Hermans, MH, Smith, L, van Aesch, YM, Schelen, AM, Antonissen, C, Touw, IP	Blood	1999
8977235	Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes Tian, SS, Tapley, P, Sincich, C, Stein, RB, Rosen, J, Lamb, P	Blood	1996
17879956	The granulocyte colony stimulating factor (G-CSF) activates Jak/STAT and MAPK pathways in a trophoblastic cell line Marino, VJ, Roguin, LP	J. Cell. Biochem.	2008

Participants

Input

Output

Participates

as an event of

Signaling by CSF3 (G-CSF) (Homo sapiens)

Catalyst Activity

protein tyrosine kinase activity of CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane]

Physical Entity

CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane] (Homo sapiens)

Activity

protein tyrosine kinase activity (GO:0004713)

This event is regulated

Negatively by

Regulator

SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)

Active Unit

SOCS-1 and SOCS-3 [cytosol]

Inferred From

p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5 (Mus musculus)

Authored

May, B (2020-01-13)

Reviewed

Touw, IP (2020-12-12)

Created

May, B (2020-01-15)