Reactome | p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm

p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm

Stable Identifier

R-HSA-9674550

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

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p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm

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Homodimers of phosphorylated STAT1, STAT3, and STAT5 and heterodimers of phosphorylated STAT1 and STAT3 translocate from the cytosol to the nucleus (Tian et al. 1994, Tian et al. 1996, Ward et al. 1999, also inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
9864153	Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration Ward, AC, Hermans, MH, Smith, L, van Aesch, YM, Schelen, AM, Antonissen, C, Touw, IP	Blood	1999
7521688	Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor Tian, SS, Lamb, P, Seidel, HM, Stein, RB, Rosen, J	Blood	1994
8977235	Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes Tian, SS, Tapley, P, Sincich, C, Stein, RB, Rosen, J, Lamb, P	Blood	1996