CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1

Stable Identifier
Reaction [uncertain]
Homo sapiens
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JAK1 is phosphorylated by an unknown kinase in response to CSF3 binding CSF3R (Nicholson et al. 1994, Tian et al. 1994, Marino and Roguin 2008). Phosphorylated JAK1 is required for subsequent phosphorylation of CSF3R (Shimoda et al. 1997, inferred from mouse homologs). The SRC-related protein kinase LYN is constitutively associated with CSF3R (Corey et al. 1994).

Literature References
PubMed ID Title Journal Year
9226159 Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor

Shimoda, K, Feng, J, Murakami, H, Nagata, S, Watling, D, Rogers, NC, Stark, GR, Kerr, IM, Ihle, JN

Blood 1997
7521688 Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor

Tian, SS, Lamb, P, Seidel, HM, Stein, RB, Rosen, J

Blood 1994
7512720 Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation

Nicholson, SE, Oates, AC, Harpur, AG, Ziemiecki, A, Wilks, AF, Layton, JE

Proc. Natl. Acad. Sci. U.S.A. 1994
8197119 Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases

Corey, SJ, Burkhardt, AL, Bolen, JB, Geahlen, RL, Tkatch, LS, Tweardy, DJ

Proc. Natl. Acad. Sci. U.S.A. 1994
17879956 The granulocyte colony stimulating factor (G-CSF) activates Jak/STAT and MAPK pathways in a trophoblastic cell line

Marino, VJ, Roguin, LP

J. Cell. Biochem. 2008
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