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AAMP binds EGFR
Stable Identifier
R-HSA-9674531
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytoplasm
,
plasma membrane
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
AAMP binds EGFR (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
AAMP (Angio-associated migratory cell protein) binds to EGFR. The interaction involves the intracellular domain of EGFR. AAMP binding, through an unknown mechanism, promotes EGFR dimerization, trans-autophosphorylation and downstream signaling, leading to activation of ERKs (MAPK1 and MAPK3) and expression of cyclin D1 (CCND1). Downregulation of AAMP inhibits proliferation of a non-small cell lung cancer (NSCLC) cell line and increases its sensitivity to EGFR-targeted chemotherapeutic drugs, and it also inhibits tumorigenesis in a mouse model (Yao et al. 2019).
In addition to lung cancer, AAMP overexpression is linked with poor prognosis in breast cancer, where AAMP level positively correlates with tumor grade. AAMP is overexpressed in breast ductal carcinoma in situ (DCIS) with necrosis (Adeyinka et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
31075398
Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells
Sun, X
,
Zhang, Y
,
Yao, S
,
Sun, W
,
Su, L
,
Liu, X
,
Shi, F
,
Wang, Y
,
Liu, X
Cell. Signal.
2019
Participants
Input
AAMP [cytosol]
(Homo sapiens)
EGFR [plasma membrane]
(Homo sapiens)
Output
EGFR:AAMP [plasma membrane]
(Homo sapiens)
Participates
as an event of
Signaling by EGFR (Homo sapiens)
Event Information
Go Biological Process
positive regulation of epidermal growth factor receptor signaling pathway (0045742)
Orthologous Events
AAMP binds EGFR (Bos taurus)
AAMP binds EGFR (Caenorhabditis elegans)
AAMP binds EGFR (Canis familiaris)
AAMP binds EGFR (Danio rerio)
AAMP binds EGFR (Drosophila melanogaster)
AAMP binds EGFR (Gallus gallus)
AAMP binds EGFR (Mus musculus)
AAMP binds EGFR (Rattus norvegicus)
AAMP binds EGFR (Sus scrofa)
AAMP binds EGFR (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2020-01-29)
Reviewed
Liu, X (2020-02-05)
Yao, S (2020-02-05)
Kinsella, BT (2020-02-06)
Mulvaney, EP (2020-02-06)
Created
Orlic-Milacic, M (2020-01-14)
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