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ponatinib-sensitive PDGFR mutants [plasma membrane]
Stable Identifier
R-HSA-9674354
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by PDGFR in disease (Homo sapiens)
PDGFR mutants bind TKIs (Homo sapiens)
PDGFR mutants bind type II TKIs (Homo sapiens)
type II TKI sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
ponatinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
type II sensitive PDGFR mutants:type II TKIs [plasma membrane] (Homo sapiens)
type II TKI sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
ponatinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
31723821
FIP1L1-PDGFRα p.T674I-D842L: A Novel and Ponatinib Resistant Compound Mutation in FIP1L1-PDGFRα Positive Leukemia
Smits, S
,
Appleby, N
,
Conneally, E
,
Vandenberghe, P
,
Michaux, L
,
Lierman, E
Hemasphere
2019
Participants
members
PDGFRA D842V [plasma membrane]
(Homo sapiens)
PDGFRA T674I [plasma membrane]
(Homo sapiens)
PDGFRA D842L [plasma membrane]
(Homo sapiens)
Participates
as a member of
type II TKI sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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