As a deubiquitinase, Ubiquitin carboxyl-terminal hydrolase 30 (USP30) can reverse the action of E3 ligase on peroxisomal membrane proteins. Studies show that USP30 can localise in the peroxisomal membrane and interact with ubiquitinated PEX5 (Riccio V et al. 2019, Marcassa E et al. 2019).
Rusilowicz-Jones, EV, Clague, MJ, Jardine, J, Marcassa, E, Urbé, S, Kallinos, A
Riccio, V, McQuibban, GA, Kim, PK
Vissa, M, Strilchuk, AW, Demers, N, Hua, R, Riccio, V, McQuibban, GA, Cheng, DT, Wang, Y, Kim, PK
© 2023 Reactome