USP30 binds ATM dimer:Ub-p-PEX5

Stable Identifier
R-HSA-9674131
Type
Reaction [binding]
Species
Homo sapiens
Compartment
peroxisomal membrane
ReviewStatus
5/5
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USP30 binds ATM dimer:Ub-p-PEX5
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As a deubiquitinase, Ubiquitin carboxyl-terminal hydrolase 30 (USP30) can reverse the action of E3 ligase on peroxisomal membrane proteins. Studies show that USP30 can localise in the peroxisomal membrane and interact with ubiquitinated PEX5 (Riccio V et al. 2019, Marcassa E et al. 2019).

Literature References
PubMed ID Title Journal Year
31356149 New aspects of USP30 biology in the regulation of pexophagy

Rusilowicz-Jones, EV, Clague, MJ, Jardine, J, Marcassa, E, Urbé, S, Kallinos, A

Autophagy 2019
31131315 USP30: protector of peroxisomes and mitochondria

Riccio, V, McQuibban, GA, Kim, PK

Mol Cell Oncol 2019
30700497 Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy

Vissa, M, Strilchuk, AW, Demers, N, Hua, R, Riccio, V, McQuibban, GA, Cheng, DT, Wang, Y, Kim, PK

J. Cell Biol. 2019
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Orthologous Events
USP30 binds ATM dimer:Ub-p-PEX5 (Bos taurus)
USP30 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)
USP30 binds ATM dimer:Ub-p-PEX5 (Danio rerio)
USP30 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
USP30 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)
USP30 binds ATM dimer:Ub-p-PEX5 (Mus musculus)
USP30 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
USP30 binds ATM dimer:Ub-p-PEX5 (Saccharomyces cerevisiae)
USP30 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)
Authored
Varusai, TM  (2020-01-06)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2020-01-10)
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