USP30 deubiquitinates ATM dimer:Ub-p-PEX5

Stable Identifier
R-HSA-9674127
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal membrane
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USP30 deubiquitinates ATM dimer:Ub-p-PEX5
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The deubiquitinase, Ubiquitin carboxyl-terminal hydrolase 30 (USP30) counters the action of E3 ligase on peroxisomal membrane proteins. USP30 can remove ubiquitin moieties from PEX5 thereby preventing pexophagy (Riccio V et al. 2019, Marcassa E et al. 2019)

Literature References
PubMed ID Title Journal Year
31131315 USP30: protector of peroxisomes and mitochondria

Riccio, V, McQuibban, GA, Kim, PK

Mol Cell Oncol 2019
31356149 New aspects of USP30 biology in the regulation of pexophagy

Marcassa, E, Kallinos, A, Jardine, J, Rusilowicz-Jones, EV, Clague, MJ, Urbé, S

Autophagy 2019
30700497 Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy

Riccio, V, Demers, N, Hua, R, Vissa, M, Cheng, DT, Strilchuk, AW, Wang, Y, McQuibban, GA, Kim, PK

J. Cell Biol. 2019
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitinyl hydrolase activity of ATM dimer:Ub-p-PEX5:USP30 [peroxisomal membrane]
Physical Entity
ATM dimer:Ub-p-PEX5:USP30 [peroxisomal membrane]
Activity
ubiquitinyl hydrolase activity (0101005)
Orthologous Events
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Caenorhabditis elegans)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Danio rerio)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Mus musculus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Sus scrofa)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Xenopus tropicalis)
Authored
Varusai, TM  (2020-01-06)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2020-01-10)