The deubiquitinase, Ubiquitin carboxyl-terminal hydrolase 30 (USP30) counters the action of E3 ligase on peroxisomal membrane proteins. USP30 can remove ubiquitin moieties from PEX5 thereby preventing pexophagy (Riccio V et al. 2019, Marcassa E et al. 2019)
Riccio, V, McQuibban, GA, Kim, PK
Marcassa, E, Kallinos, A, Jardine, J, Rusilowicz-Jones, EV, Clague, MJ, Urbé, S
Riccio, V, Demers, N, Hua, R, Vissa, M, Cheng, DT, Strilchuk, AW, Wang, Y, McQuibban, GA, Kim, PK
ubiquitinyl hydrolase activity of ATM dimer:Ub-p-PEX5:USP30 [peroxisomal membrane]
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