USP30 deubiquitinates ATM dimer:Ub-p-PEX5

Stable Identifier
R-HSA-9674127
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
USP30 deubiquitinates ATM dimer:Ub-p-PEX5
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The deubiquitinase, Ubiquitin carboxyl-terminal hydrolase 30 (USP30) counters the action of E3 ligase on peroxisomal membrane proteins. USP30 can remove ubiquitin moieties from PEX5 thereby preventing pexophagy (Riccio V et al. 2019, Marcassa E et al. 2019)

Literature References
PubMed ID Title Journal Year
31356149 New aspects of USP30 biology in the regulation of pexophagy

Rusilowicz-Jones, EV, Clague, MJ, Jardine, J, Marcassa, E, Urbé, S, Kallinos, A

Autophagy 2019
31131315 USP30: protector of peroxisomes and mitochondria

Riccio, V, McQuibban, GA, Kim, PK

Mol Cell Oncol 2019
30700497 Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy

Vissa, M, Strilchuk, AW, Demers, N, Hua, R, Riccio, V, McQuibban, GA, Cheng, DT, Wang, Y, Kim, PK

J. Cell Biol. 2019
Participants
Input
Output
Participates
as an event of
Catalyst Activity

deubiquitinase activity of ATM dimer:Ub-p-PEX5:USP30 [peroxisomal membrane]

Physical Entity
ATM dimer:Ub-p-PEX5:USP30 [peroxisomal membrane] (Homo sapiens)
Activity
deubiquitinase activity (GO:0101005)
Orthologous Events
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Danio rerio)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Mus musculus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Sus scrofa)
Authored
Varusai, TM  (2020-01-06)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2020-01-10)
Cite Us!