The deubiquitinase, Ubiquitin carboxyl-terminal hydrolase 30 (USP30) counters the action of E3 ligase on peroxisomal membrane proteins. USP30 can remove ubiquitin moieties from PEX5 thereby preventing pexophagy (Riccio V et al. 2019, Marcassa E et al. 2019)
Rusilowicz-Jones, EV, Clague, MJ, Jardine, J, Marcassa, E, Urbé, S, Kallinos, A
Riccio, V, McQuibban, GA, Kim, PK
Vissa, M, Strilchuk, AW, Demers, N, Hua, R, Riccio, V, McQuibban, GA, Cheng, DT, Wang, Y, Kim, PK
deubiquitinase activity of ATM dimer:Ub-p-PEX5:USP30 [peroxisomal membrane]
© 2023 Reactome