NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen

Stable Identifier
Reaction [transition]
Homo sapiens
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The activity of the non-phagocytic NADPH oxidase 1 (NOX1) complex, composed of NOX1, NOXA1, NOXO1 and CYBA, is greatly enhanced upon RAC1:GTP binding, resulting in production of the superoxide O2- which can serve as a second messenger (Takeya et al. 2003, Miyano et al. 2006, Park et al. 2006, Cheng et al. 2006).

Literature References
PubMed ID Title Journal Year
16636067 Nox1-dependent reactive oxygen generation is regulated by Rac1

Lambeth, JD, Diebold, BA, Hughes, Y, Cheng, G

J. Biol. Chem. 2006
16329988 Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1

Park, HS, Bae, YS, Park, D

Biochem. Biophys. Res. Commun. 2006
16762923 Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1

Takeya, R, Miyano, K, Sumimoto, H, Ueno, N

J. Biol. Chem. 2006
12716910 Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases

Takeya, R, Taura, M, Sumimoto, H, Kami, K, Ueno, N, Izaki, T, Nunoi, H, Kohjima, M

J. Biol. Chem. 2003
Catalyst Activity

superoxide-generating NAD(P)H oxidase activity of NOX1 complex:WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane]

Cross References
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