ppDVL:RAC1:GTP binds NOX1 complex

Stable Identifier
R-HSA-9673794
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Activated RAC1 (RAC1:GTP) binds NADPH oxidase NOX1 complex composed of NOX1, NOXA1, NOXO1 and CYBA (p22phox). RAC1 directly interacts with a conserved region in NOX1 and with tetratricopeptide repeats in NOXA1 (Takeya et al. 2003, Park et al. 2006, Cheng et al. 2006, Miyano et al. 2006, Kao et al. 2008)

Literature References
PubMed ID Title Journal Year
16636067 Nox1-dependent reactive oxygen generation is regulated by Rac1

Cheng, G, Diebold, BA, Hughes, Y, Lambeth, JD

J. Biol. Chem. 2006
11779461 Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1

Habas, R, Kato, Y, He, X

Cell 2001
8947551 Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila

Eaton, S, Wepf, R, Simons, K

J. Cell Biol. 1996
16329988 Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1

Park, HS, Park, D, Bae, YS

Biochem. Biophys. Res. Commun. 2006
16762923 Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1

Miyano, K, Ueno, N, Takeya, R, Sumimoto, H

J. Biol. Chem. 2006
18347018 Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism

Kao, YY, Gianni, D, Bohl, B, Taylor, RM, Bokoch, GM

J. Biol. Chem. 2008
12716910 Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases

Takeya, R, Ueno, N, Kami, K, Taura, M, Kohjima, M, Izaki, T, Nunoi, H, Sumimoto, H

J. Biol. Chem. 2003
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