Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB

Stable Identifier
R-HSA-9673760
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Transmembrane PDGFR fusion proteins dimerize independent of ligand stimulation, driven by the presence of a dimerization domain provided by the N-terminal fusion partner of the PDGFR protein (Stover et al, 2006; Carroll et al, 1996; Ozawa et al, 2010; Medves et al, 2010; Willbanks et al, 2000; reviewed in Wang et al, 2016; Appiah-Kubi et al, 2017).

Literature References
PubMed ID Title Journal Year
16690743 Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent

Stover, EH, Chen, J, Folens, C, Lee, BH, Mentens, N, Marynen, P, Williams, IR, Gilliland, DG, Cools, J

Proc. Natl. Acad. Sci. U.S.A. 2006
27170215 The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are major players in oncogenesis, drug resistance, and attractive oncologic targets in cancer

Wang, Y, Appiah-Kubi, K, Wu, M, Yao, X, Qian, H, Wu, Y, Chen, Y

Growth Factors 2016
8962143 The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

Carroll, M, Tomasson, MH, Barker, GF, Golub, TR, Gilliland, DG

Proc. Natl. Acad. Sci. U.S.A. 1996
28010895 Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies

Appiah-Kubi, K, Lan, T, Wang, Y, Qian, H, Wu, M, Yao, X, Wu, Y, Chen, Y

Crit. Rev. Oncol. Hematol. 2017
10812249 TEL/PDGFbetaR fusion protein activates STAT1 and STAT5: a common mechanism for transformation by tyrosine kinase fusion proteins

Wilbanks, AM, Mahajan, S, Frank, DA, Druker, BJ, Gilliland, DG, Carroll, M

Exp. Hematol. 2000
20889717 PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

Ozawa, T, Brennan, CW, Wang, L, Squatrito, M, Sasayama, T, Nakada, M, Huse, JT, Pedraza, A, Utsuki, S, Yasui, Y, Tandon, A, Fomchenko, EI, Oka, H, Levine, RL, Fujii, K, Ladanyi, M, Holland, EC

Genes Dev. 2010
20164854 KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia

Medves, S, Duhoux, FP, Ferrant, A, Toffalini, F, Ameye, G, Libouton, JM, Poirel, HA, Demoulin, JB

Leukemia 2010
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
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