WNT5 binds FZD7

Stable Identifier
R-HSA-9673349
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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WNT5 binds FZD7
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Non-canonical WNT5A pathways (the ones that do not induce the activation of β-catenin) are usually initiated by the binding of WNT5A to FZD receptors, including FZD7 (Nishita et al. 2010 & Anastas et al. 2014).
Literature References
PubMed ID Title Journal Year
20457807 Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization

Kikuchi, A, Minami, Y, Inaba, D, Takada, S, Qiao, S, Itsukushima, S, Wang, Z, Endo, M, Nomachi, A, Nishita, M

Mol. Cell. Biol. 2010
24865425 WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors

Rizos, H, Toroni, RA, Yang, PT, Moon, RT, Kulikauskas, RM, von Euw, EM, Chen, HW, Long, GV, Chien, AJ, Lucero, OM, Anastas, JN, Tamir, T, Haydu, L

J. Clin. Invest. 2014
Participants
Input
Output
Participates
as an event of
Authored
Jassal, B  (2020-01-07)
Murillo, JI  (2019-10-22)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2020-01-07)
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