WNT5:FZD7 binds p-DVL

Stable Identifier
Reaction [binding]
Homo sapiens
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The DEP domain of dishevelled proteins (DVL) is required both for planar cell polarization (PCP) signaling and for membrane localization upon WNT activation (Boutros et al, 1998; Axelrod et al, 2001; Rothbacher et al, 2000, Wong et al, 2000; Park et al, 2005; Witzel et al, 2006). Although DVL interacts with FZD through its PDZ domain, disruption of this binding interface does not interfere with non-canonical signaling (Wong et al, 2003). Membrane recruitment of DVL and establishment of PCP may also rely on other interacting partners (Lee et al, 2007; Li et al, 2013).

Literature References
PubMed ID Title Journal Year
17130287 Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane

Heisenberg, CP, Tada, M, Carreira-Barbosa, F, Witzel, S, Zimyanin, V

J. Cell Biol. 2006
15936275 Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos

Sato, A, Gray, RS, Habas, R, Wallingford, JB, Park, TJ

Curr. Biol. 2005
11101902 Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway

Wong, HC, Liu, B, Nguyen, JT, Li, L, Srinivas, S, Zheng, J, Mao, J, Zhang, W, Wu, D

Nat. Struct. Biol. 2000
12015986 Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling

Axelrod, JD, Tree, DR, Shulman, JM, Gubb, D, Scott, MP, Rousset, R

Cell 2002
10698942 Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis

Laurent, MN, Rothbächer, U, Klein, PS, Deardorff, MA, Cho, KW, Fraser, SE

EMBO J. 2000
23821037 Gpr125 modulates Dishevelled distribution and planar cell polarity signaling

Li, X, Ni, M, Roszko, I, Marlow, FL, Hamm, HE, Solnica-Krezel, L, Sepich, DS

Development 2013
9674432 Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

Boutros, M, Mlodzik, M, Paricio, N, Strutt, DI

Cell 1998
9716412 Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

Axelrod, JD, Shulman, JM, Miller, JR, Perrimon, N, Moon, RT

Genes Dev 1998
17627283 XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway

Kinoshita, N, Natsume, T, Iioka, H, Ohashi, M, Iemura, S, Lee, RH

EMBO J. 2007
11358862 Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling

Axelrod, JD

Genes Dev. 2001
14636582 Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

Shi, DL, Zheng, J, Wu, D, Shao, Y, Wong, HC, Lee, HJ, Bourdelas, A, Mlodzik, M, Krauss, A

Mol Cell 2003
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