NBEA binds GLRB

Stable Identifier
R-HSA-9673173
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Binding of NBEA to GLRB (glycine receptor beta subunit) was demonstrated by co-immunoprecipitation of recombinant rat Glrb with endogenous Nbea from rat brain, as well as co-immunoprecipitation of recombinant rat Glrb with recombinant mouse Nbea. It was also shown, by immunocytochemistry, that NBEA and glycine receptor co-localize at postsynaptic densities of inhibitory synapses (del Pino et al. 2011). NBEA may be involved in trafficking of glycine receptors to the plasma membrane. As glycine receptors are pre-assembled at the endoplasmic reticulum (Griffon et al. 1999), the reaction diagram depicts binding of NBEA to this pre-assembled receptor complex, consisting of glycine receptor alpha and beta subunits.

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