SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix

Stable Identifier
R-HSA-9672770
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mitochondrial uptake of the three branched-chain amino acids leucine (Leu), isoleucine (Ile), and valine (Val) is mediated by solute carrier family 25 member 44 (SLC25A44), localized in the inner mitochondrial membrane. This human reaction is inferred from studies of the homologous mouse protein, Slc25a44 (Yoneshiro et al. 2019).

Literature References
PubMed ID Title Journal Year
31435015 BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

Yoneshiro, T, Wang, Q, Tajima, K, Matsushita, M, Maki, H, Igarashi, K, Dai, Z, White, PJ, McGarrah, RW, Ilkayeva, OR, Deleye, Y, Oguri, Y, Kuroda, M, Ikeda, K, Li, H, Ueno, A, Ohishi, M, Ishikawa, T, Kim, K, Chen, Y, Sponton, CH, Pradhan, RN, Majd, H, Greiner, VJ, Yoneshiro, M, Brown, Z, Chondronikola, M, Takahashi, H, Goto, T, Kawada, T, Sidossis, L, Szoka, FC, McManus, MT, Saito, M, Soga, T, Kajimura, S

Nature 2019
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
branched-chain amino acid transmembrane transporter activity of SLC25A44 [mitochondrial inner membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created