FIP1L1(1-395):PDGFRA (585-1069) fusion [cytosol]

Stable Identifier
R-HSA-9672506
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
12660384 A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

Cools, J, Deangelo, DJ, Gotlib, J, Stover, EH, Legare, RD, Cortes, J, Kutok, J, Clark, J, Galinsky, I, Griffin, JD, Cross, NC, Tefferi, A, Malone, J, Alam, R, Schrier, SL, Schmid, J, Rose, M, Vandenberghe, P, Verhoef, G, Boogaerts, M, Wlodarska, I, Kantarjian, H, Marynen, P, Coutré, SE, Stone, R, Gilliland, DG

N. Engl. J. Med. 2003
15070659 The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management

Gotlib, J, Cools, J, Malone, JM, Schrier, SL, Gilliland, DG, Coutré, SE

Blood 2004
External Reference Information
External Reference
Gene Names
FIP1L1, FIP1, RHE
Chain
chain:1-594
Other Identifiers
0006980204
11743936_a_at
11751233_a_at
11759532_at
11759533_s_at
1554424_at
16966748
221007_s_at
2727227
2727228
2727229
2727232
2727234
2727235
2727236
2727238
2727239
2727240
2727242
2727244
2727245
2727246
2727249
2727252
2727253
2727258
2727263
2727265
2727268
2727269
2727274
2727275
2727276
2727277
2727278
2727279
43072_s_at
58459_s_at
8095048
A_23_P58337
A_24_P20623
A_24_P265162
GE83194
GO:0000398
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005847
GO:0006369
GO:0006378
GO:0006397
GO:0006406
GO:0006810
GO:0006913
GO:0008150
GO:0009058
GO:0015031
GO:0031124
GO:0032991
GO:0034641
GO:0043226
GO:0098789
Hs.66295.2.A1_3p_at
Hs2.334812.2.S1_3p_s_at
ILMN_1768743
ILMN_2190942
PH_hs_0016478
TC04002930.hg
g13569873_3p_s_at
Participant Of
Other forms of this molecule
Modified Residues
Name
Replacement of residues 392 to 395 by GDCY
Name
Insertion of residues 585 to 1069 at 396 from UniProt:P16234 PDGFRA
Coordinate
396
Disease
Name Identifier Synonyms
hypereosinophilic syndrome 999 Eosinophilic leukocytosis, eosinophilia