Defective F8 binding to the cell membrane

Stable Identifier
R-HSA-9672395
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The Reactome event describes the defective interaction between the thrombin-activated FVIIIa protein and phospholipid membrane surfaces caused by hemophilia A-associated FVIII variants, such as A2220P, A2220del and Q2330P.

Literature References
PubMed ID Title Journal Year
25354705 Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding

Du, J, Wichapong, K, Hackeng, KM, Nicolaes, GA

Thromb. Haemost. 2015
15471879 Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities

Spiegel, PC, Murphy, P, Stoddard, BL

J. Biol. Chem. 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
factor VIII deficiency 12134 Congenital factor VIII disorder, Subhemophilia, Hemophilia A
Authored
Reviewed
Created
Cite Us!