Defective F8 binding to the cell membrane

Stable Identifier
R-HSA-9672395
Type
Pathway
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Defective F8 binding to the cell membrane
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The Reactome event describes the defective interaction between the thrombin-activated FVIIIa protein and phospholipid membrane surfaces caused by hemophilia A-associated FVIII variants, such as A2220P, A2220del and Q2330P.
Literature References
PubMed ID Title Journal Year
15471879 Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities

Spiegel, PC, Stoddard, BL, Murphy, P

J. Biol. Chem. 2004
25354705 Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding

Nicolaes, GA, Wichapong, K, Hackeng, KM, Du, J

Thromb. Haemost. 2015
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
factor VIII deficiency DOID:12134 Congenital factor VIII disorder, Subhemophilia, Hemophilia A
Cross References
BioModels Database
Authored
Shamovsky, V  (2019-09-09)
Reviewed
D'Eustachio, P  (2020-01-09)
Zhang, B  (2020-04-02)
Created
Shamovsky, V  (2019-12-25)
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