PI3-kinase binds to PDGFRA extracellular domain dimers

Stable Identifier
R-HSA-9672178
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PI3K-mediated signaling has been demonstrated downstream of PDGFRA Y288C and PDGFRA(del375-455) as assessed by the presence of phosphorylated AKT (Ozawa et al, 2010; Ip et al, 2018).

Literature References
PubMed ID Title Journal Year
20889717 PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

Ozawa, T, Brennan, CW, Wang, L, Squatrito, M, Sasayama, T, Nakada, M, Huse, JT, Pedraza, A, Utsuki, S, Yasui, Y, Tandon, A, Fomchenko, EI, Oka, H, Levine, RL, Fujii, K, Ladanyi, M, Holland, EC

Genes Dev. 2010
30389923 Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Ip, CKM, Ng, PKS, Jeong, KJ, Shao, SH, Ju, Z, Leonard, PG, Hua, X, Vellano, CP, Woessner, R, Sahni, N, Scott, KL, Mills, GB

Nat Commun 2018
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
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