STAT binds to the mutant PDGFRA receptor

Stable Identifier
R-HSA-9672176
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Like the WT receptor, gain-of-function missense and in-frame deletion mutants of PDGFRA appear to act through the STAT signaling pathway. Binding and phosphorylation of SRC and subsequently STAT1 and 3 has been demonstrated for the activation loop D842V mutant, the juxtamembrane domain V561D mutant and for a small number of short in-frame deletion mutants in the kinase and juxtamembrane domain region. Specificity for interaction with different STAT family members is likely to vary depending on the PDGFRA mutation (Heinrich et al, 2003; Velghe et al, 2014; reviewed in Klug et al, 2018; Wang et al, 2016; Corless et al, 2011).

Literature References
PubMed ID Title Journal Year
22089421 Gastrointestinal stromal tumours: origin and molecular oncology

Corless, CL, Barnett, CM, Heinrich, MC

Nat. Rev. Cancer 2011
27170215 The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are major players in oncogenesis, drug resistance, and attractive oncologic targets in cancer

Wang, Y, Appiah-Kubi, K, Wu, M, Yao, X, Qian, H, Wu, Y, Chen, Y

Growth Factors 2016
12522257 PDGFRA activating mutations in gastrointestinal stromal tumors

Heinrich, MC, Corless, CL, Duensing, A, McGreevey, L, Chen, CJ, Joseph, N, Singer, S, Griffith, DJ, Haley, A, Town, A, Demetri, GD, Fletcher, CD, Fletcher, JA

Science 2003
29964125 Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases

Klug, LR, Kent, JD, Heinrich, MC

Pharmacol. Ther. 2018
23752188 PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations

Velghe, AI, Van Cauwenberghe, S, Polyansky, AA, Chand, D, Montano-Almendras, CP, Charni, S, Hallberg, B, Essaghir, A, Demoulin, JB

Oncogene 2014
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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