Ligand-independent dimerization of PDGFRA extracellular domain mutants

Stable Identifier
R-HSA-9672174
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Extracellular domain mutants of PDGFRA such as Y288C and PDGFRA del375-455 signal constitutively from intracellular compartments in the absence of stimulation by ligand (Clarke and Dirks, 2003; Ozawa et al, 2010; Paugh et al, 2013; Ip et al, 2018). Mislocalization of these proteins may result from inadequate glycosylation, trapping them in the endoplasmic reticulum, or rapid endocytosis from the plasma membrane.

Literature References
PubMed ID Title Journal Year
12569364 A human brain tumor-derived PDGFR-alpha deletion mutant is transforming

Clarke, ID, Dirks, PB

Oncogene 2003
30389923 Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Ip, CKM, Ng, PKS, Jeong, KJ, Shao, SH, Ju, Z, Leonard, PG, Hua, X, Vellano, CP, Woessner, R, Sahni, N, Scott, KL, Mills, GB

Nat Commun 2018
20889717 PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

Ozawa, T, Brennan, CW, Wang, L, Squatrito, M, Sasayama, T, Nakada, M, Huse, JT, Pedraza, A, Utsuki, S, Yasui, Y, Tandon, A, Fomchenko, EI, Oka, H, Levine, RL, Fujii, K, Ladanyi, M, Holland, EC

Genes Dev. 2010
23970477 Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas

Paugh, BS, Zhu, X, Qu, C, Endersby, R, Diaz, AK, Zhang, J, Bax, DA, Carvalho, D, Reis, RM, Onar-Thomas, A, Broniscer, A, Wetmore, C, Zhang, J, Jones, C, Ellison, DW, Baker, SJ

Cancer Res. 2013
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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