SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers

Stable Identifier
R-HSA-9672163
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SOS-mediated nucleotide exchange on RAS is likely promoted by extracellular domain mutants of PDGFRA, as evidenced by the increased levels of phosphorylated MAPK/ERK proteins, although the details have not been fully demonstrated (Ozawa et al, 2010; Ip et al, 2018).

Literature References
PubMed ID Title Journal Year
20889717 PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

Ozawa, T, Brennan, CW, Wang, L, Squatrito, M, Sasayama, T, Nakada, M, Huse, JT, Pedraza, A, Utsuki, S, Yasui, Y, Tandon, A, Fomchenko, EI, Oka, H, Levine, RL, Fujii, K, Ladanyi, M, Holland, EC

Genes Dev. 2010
30389923 Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Ip, CKM, Ng, PKS, Jeong, KJ, Shao, SH, Ju, Z, Leonard, PG, Hua, X, Vellano, CP, Woessner, R, Sahni, N, Scott, KL, Mills, GB

Nat Commun 2018
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of p-11Y PDGFRA extracellular domain dimers:GRB2:SOS1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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