STAT binds to p-11Y PDGFRA extracellular domain dimers

Stable Identifier
R-HSA-9672159
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
STAT binds to p-11Y PDGFRA extracellular domain dimers
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
STAT signaling is activated downstream of the PDGFRA Y288C extracellular domain mutant, similar to the wild-type receptor (Ip et al, 2018).
Literature References
PubMed ID Title Journal Year
30389923 Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Ip, CKM, Ng, PKS, Jeong, KJ, Shao, SH, Ju, Z, Leonard, PG, Hua, X, Vellano, CP, Woessner, R, Sahni, N, Scott, KL, Mills, GB

Nat Commun 2018
Participants
Input
Output
Participates
as an event of
Functional status

Gain of function of extracellular domain mutant PDGFRA dimers [endoplasmic reticulum membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2020-02-25)
Reviewed
Ip, CKM  (2020-02-06)
Created
Rothfels, K  (2019-12-23)
Cite Us!