STAT binds to p-11Y PDGFRA extracellular domain dimers

Stable Identifier
R-HSA-9672159
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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General
SVG |   | PPTX  | SBGN
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STAT signaling is activated downstream of the PDGFRA Y288C extracellular domain mutant, similar to the wild-type receptor (Ip et al, 2018).

Literature References
PubMed ID Title Journal Year
30389923 Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Ip, CKM, Ng, PKS, Jeong, KJ, Shao, SH, Ju, Z, Leonard, PG, Hua, X, Vellano, CP, Woessner, R, Sahni, N, Scott, KL, Mills, GB

Nat Commun 2018
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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