Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants

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R-HSA-9670439
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Pathway
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Homo sapiens
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Activation of the PI3K/mTOR, RAS/MAPK and STAT signaling pathways has been observed downstream of activated extracellular, juxtamembrane and kinase domain mutants of KIT, although downstream signaling has not been studied in great detail in all cases. Activation of these pathways contributes to cellular proliferation, avoidance of apoptosis, and actin cytoskeletal organization (Dunesing et al, 2004; Bauer et al, 2007; Chi et al, 2010; Bosbach et al, 2017; reviewed in Lennartsson and Roonstrand, 2012; Corless et al, 2011).

Literature References
PubMed ID Title Journal Year
20927104 ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours

Chi, P, Chen, Y, Zhang, L, Guo, X, Wongvipat, J, Shamu, T, Fletcher, JA, Dewell, S, Maki, RG, Zheng, D, Antonescu, CR, Allis, CD, Sawyers, CL

Nature 2010
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Lennartsson, J, Rönnstrand, L

Physiol. Rev. 2012
22089421 Gastrointestinal stromal tumours: origin and molecular oncology

Corless, CL, Barnett, CM, Heinrich, MC

Nat. Rev. Cancer 2011
15007386 Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)

Duensing, A, Medeiros, F, McConarty, B, Joseph, NE, Panigrahy, D, Singer, S, Fletcher, CD, Demetri, GD, Fletcher, JA

Oncogene 2004
28923937 Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor

Bosbach, B, Rossi, F, Yozgat, Y, Loo, J, Zhang, JQ, Berrozpe, G, Warpinski, K, Ehlers, I, Veach, D, Kwok, A, Manova, K, Antonescu, CR, DeMatteo, RP, Besmer, P

Proc. Natl. Acad. Sci. U.S.A. 2017
17546049 KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway

Bauer, S, Duensing, A, Demetri, GD, Fletcher, JA

Oncogene 2007
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Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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