Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Activation of the PI3K/mTOR, RAS/MAPK and STAT signaling pathways has been observed downstream of activated extracellular, juxtamembrane and kinase domain mutants of KIT, although downstream signaling has not been studied in great detail in all cases. Activation of these pathways contributes to cellular proliferation, avoidance of apoptosis, and actin cytoskeletal organization (Dunesing et al, 2004; Bauer et al, 2007; Chi et al, 2010; Bosbach et al, 2017; reviewed in Lennartsson and Roonstrand, 2012; Corless et al, 2011).

Literature References
PubMed ID Title Journal Year
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Rönnstrand, L, Lennartsson, J

Physiol. Rev. 2012
20927104 ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours

Dewell, S, Antonescu, CR, Chen, Y, Maki, RG, Zhang, L, Sawyers, CL, Allis, CD, Shamu, T, Guo, X, Fletcher, JA, Zheng, D, Chi, P, Wongvipat, J

Nature 2010
22089421 Gastrointestinal stromal tumours: origin and molecular oncology

Barnett, CM, Corless, CL, Heinrich, MC

Nat. Rev. Cancer 2011
15007386 Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)

McConarty, B, Medeiros, F, Fletcher, JA, Demetri, GD, Singer, S, Fletcher, CD, Panigrahy, D, Joseph, NE, Duensing, A

Oncogene 2004
28923937 Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor

Antonescu, CR, Veach, D, Ehlers, I, Yozgat, Y, Warpinski, K, Besmer, P, Zhang, JQ, Kwok, A, Bosbach, B, Loo, J, Berrozpe, G, Rossi, F, Manova, K, DeMatteo, RP

Proc. Natl. Acad. Sci. U.S.A. 2017
17546049 KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway

Demetri, GD, Bauer, S, Fletcher, JA, Duensing, A

Oncogene 2007
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database
Cite Us!