KIT mutants bind SFKs

Stable Identifier
R-HSA-9670414
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
KIT mutants bind SFKs
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Signaling downstream of KIT mutants occurs in part through SRC family kinases, as is the case for the wild-type receptor (Paronetto et al, 2004; Krystal et al, 1998; Schittenhelm et al, 2006; Tatton et al, 2003; Timokhina et al, 1998; reviewed in Lanneartsson and Roonstrand, 2012). The dependence of different KIT mutants on SRC family signaling varies, however, with mutants such as the common D816V showing less requirement for SFK-mediated signaling (Sun et al, 2009).
Literature References
PubMed ID Title Journal Year
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Lennartsson, J, Rönnstrand, L

Physiol. Rev. 2012
9799234 Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

Timokhina, I, Kissel, H, Stella, G, Besmer, P

EMBO J 1998
9788619 Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1

Krystal, GW, DeBerry, CS, Linnekin, D, Litz, J

Cancer Res 1998
12511554 Src family kinases are involved in the differential signaling from two splice forms of c-Kit

Voytyuk, O, Lennartsson, J, Mogi, A, Caruana, G, Courtneidge, S, Ashman, LK, Rönnstrand, L

J. Biol. Chem. 2003
19265199 The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction

Sun, J, Pedersen, M, Rönnstrand, L

J. Biol. Chem. 2009
15039213 Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancer

Paronetto, MP, Farini, D, Sammarco, I, Maturo, G, Vespasiani, G, Geremia, R, Rossi, P, Sette, C

Am. J. Pathol. 2004
12475982 The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases

Tatton, L, Morley, GM, Chopra, R, Khwaja, A

J. Biol. Chem. 2003
16397263 Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies

Schittenhelm, MM, Shiraga, S, Schroeder, A, Corbin, AS, Griffith, D, Lee, FY, Bokemeyer, C, Deininger, MW, Druker, BJ, Heinrich, MC

Cancer Res. 2006
Participants
Input
Output
Participates
as an event of
Normal reaction
Interaction of Src family kinases with p-KIT (Homo sapiens)
Functional status

Gain of function of p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2020-04-01)
Reviewed
Serrano, C  (2020-03-13)
García-Valverde, A  (2020-03-13)
Pilco-Janeta, D  (2020-03-13)
Created
Rothfels, K  (2019-12-09)
Cite Us!