TERRA transcription

Stable Identifier
R-HSA-9670149
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Transcription of the telomeric noncoding RNA TERRA (the telomere repeat-containing RNA) is inhibited by ATRX (Flynn et al. 2015). Tumors with ATRX and DAXX mutations associated with the alternative lengthening of telomeres (ALT) show increased TERRA levels (Barthel et al. 2017).

Literature References
PubMed ID Title Journal Year
25593184 Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

Flynn, RL, Cox, KE, Jeitany, M, Wakimoto, H, Bryll, AR, Ganem, NJ, Bersani, F, Pineda, JR, SuvĂ , ML, Benes, CH, Haber, DA, Boussin, FD, Zou, L

Science 2015
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Catalyst Activity
Catalyst Activity
Title
DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
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Activity
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