TERRA transcription

Stable Identifier
R-HSA-9670149
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TERRA transcription
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Transcription of the telomeric noncoding RNA TERRA (the telomere repeat-containing RNA) is inhibited by ATRX (Flynn et al. 2015). Tumors with ATRX and DAXX mutations associated with the alternative lengthening of telomeres (ALT) show increased TERRA levels (Barthel et al. 2017).
Literature References
PubMed ID Title Journal Year
25593184 Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

Bersani, F, Boussin, FD, Flynn, RL, Haber, DA, Wakimoto, H, Benes, CH, Suvà, ML, Jeitany, M, Cox, KE, Ganem, NJ, Zou, L, Bryll, AR, Pineda, JR

Science 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]

Physical Entity
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm] (Homo sapiens)
Activity
DNA-directed 5'-3' RNA polymerase activity (GO:0003899)
This event is regulated
Negatively by
Regulator
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Homo sapiens)
Active Unit
ATRX:DAXX [nucleoplasm]
Authored
Orlic-Milacic, M  (2019-12-19)
Reviewed
Hayashi, MT  (2020-04-29)
Created
Orlic-Milacic, M  (2019-12-04)
Cite Us!