Transcription of the telomeric noncoding RNA TERRA (the telomere repeat-containing RNA) is inhibited by ATRX (Flynn et al. 2015). Tumors with ATRX and DAXX mutations associated with the alternative lengthening of telomeres (ALT) show increased TERRA levels (Barthel et al. 2017).
Bersani, F, Boussin, FD, Flynn, RL, Haber, DA, Wakimoto, H, Benes, CH, Suvà, ML, Jeitany, M, Cox, KE, Ganem, NJ, Zou, L, Bryll, AR, Pineda, JR
DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
© 2022 Reactome
