Reactome | ATRX:DAXX binds to subtelomeric chromosomal regions

ATRX:DAXX binds to subtelomeric chromosomal regions

Stable Identifier

R-HSA-9670101

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ATRX:DAXX binds to subtelomeric chromosomal regions

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The complex of ATRX (Alpha-thalassemia mental retardation syndrome X-linked) and DAXX (Death domain-associated protein 6) binds to subtelomeric chromosomal regions and plays a role in the recruitment of cohesin to subtelomeric regions and in the regulation of transcription of the noncoding telomeric repeat-containing RNA (TERRA) (Eid et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26055325	Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells Augé-Gouillou, C, Demattei, MV, Decottignies, A, Eid, R, Grandin, N, Charbonneau, M, Episkopou, H	Mol. Cell. Biol.	2015