Reactome | ATRX:DAXX binds to subtelomeric chromosomal regions

ATRX:DAXX binds to subtelomeric chromosomal regions

Stable Identifier

R-HSA-9670101

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ATRX:DAXX binds to subtelomeric chromosomal regions

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The complex of ATRX (Alpha-thalassemia mental retardation syndrome X-linked) and DAXX (Death domain-associated protein 6) binds to subtelomeric chromosomal regions and plays a role in the recruitment of cohesin to subtelomeric regions and in the regulation of transcription of the noncoding telomeric repeat-containing RNA (TERRA) (Eid et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26055325	Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells Eid, R, Demattei, MV, Episkopou, H, Augé-Gouillou, C, Decottignies, A, Grandin, N, Charbonneau, M	Mol. Cell. Biol.	2015