Phosphorylation of juxtamembrane domain KIT mutants

Stable Identifier
R-HSA-9669911
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Juxtamembrane mutations in KIT lead to constitutive, ligand-independent autophosphorylation of receptor, activating downstream signaling (Hirota et al, 1998; Kitayama et al, 1995; Tsujimura et al, 1994; Furitsu et al, 1993; reviewed in Roskoski, 2018).

Literature References
PubMed ID Title Journal Year
7513208 Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation

Tsujimura, T, Furitsu, T, Morimoto, M, Isozaki, K, Nomura, S, Matsuzawa, Y, Kitamura, Y, Kanakura, Y

Blood 1994
29704617 The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders

Roskoski, R

Pharmacol. Res. 2018
9438854 Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

Hirota, S, Isozaki, K, Moriyama, Y, Hashimoto, K, Nishida, T, Ishiguro, S, Kawano, K, Hanada, M, Kurata, A, Takeda, M, Muhammad Tunio, G, Matsuzawa, Y, Kanakura, Y, Shinomura, Y, Kitamura, Y

Science 1998
7530509 Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines

Kitayama, H, Kanakura, Y, Furitsu, T, Tsujimura, T, Oritani, K, Ikeda, H, Sugahara, H, Mitsui, H, Kanayama, Y, Kitamura, Y, Matsuzawa, Y

Blood 1995
7691885 Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

Furitsu, T, Tsujimura, T, Tono, T, Ikeda, H, Kitayama, H, Koshimizu, U, Sugahara, H, Butterfield, JH, Ashman, LK, Kanayama, Y, Matsuzawa, Y, Kitamura, Y, Kanakura, Y

J. Clin. Invest. 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of juxtamembrane domain KIT mutant dimers [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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