KIT binds type I TKIs

Stable Identifier
R-HSA-9669893
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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KIT can be bound and inhibited by class I tyrosine kinase inhibitors including dovitinib and midostaurin, among others. Type I inhibitors bind in the ATP binding site of the active conformation and prevent activation of the kinase (reviewed in Roskoski, 2018; Abbbaspour Babaei et al, 2016).

Literature References
PubMed ID Title Journal Year
29704617 The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders

Roskoski, R

Pharmacol. Res. 2018
27536065 Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells

Abbaspour Babaei, M, Kamalidehghan, B, Saleem, M, Huri, HZ, Ahmadipour, F

Drug Des Devel Ther 2016
Participants
Participant Of
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