KIT can be bound and inhibited by class I tyrosine kinase inhibitors including dovitinib and midostaurin, among others. Type I inhibitors bind in the ATP binding site of the active conformation and prevent activation of the kinase (reviewed in Roskoski, 2018; Abbbaspour Babaei et al, 2016).
Roskoski, R
Abbaspour Babaei, M, Kamalidehghan, B, Saleem, M, Huri, HZ, Ahmadipour, F
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