Masitinib-resistant KIT mutants do not bind masitinib

Stable Identifier
R-HSA-9669863
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated KIT receptors with oncogenic mutations in the ATP-binding cleft and the activation loop of the kinase are resistant to inhibition with masitinib (Serrano et al, 2019).

Literature References
PubMed ID Title Journal Year
30792533 Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours

Serrano, C, Mariño-Enríquez, A, Tao, DL, Ketzer, J, Eilers, G, Zhu, M, Yu, C, Mannan, AM, Rubin, BP, Demetri, GD, Raut, CP, Presnell, A, McKinley, A, Heinrich, MC, Czaplinski, JT, Sicinska, E, Bauer, S, George, S, Fletcher, JA

Br. J. Cancer 2019
Participants
Participates
Normal reaction
Functional status

Loss of function of masitinib resistant KIT mutants [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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Reviewed
Created
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