Masitinib-resistant KIT mutants do not bind masitinib

Stable Identifier
R-HSA-9669863
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Masitinib-resistant KIT mutants do not bind masitinib
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Activated KIT receptors with oncogenic mutations in the ATP-binding cleft and the activation loop of the kinase are resistant to inhibition with masitinib (Serrano et al, 2019).
Literature References
PubMed ID Title Journal Year
30792533 Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours

Heinrich, MC, Ketzer, J, Bauer, S, Zhu, M, Presnell, A, Raut, CP, George, S, Mannan, AM, Serrano, C, Yu, C, Sicinska, E, Tao, DL, Rubin, BP, Fletcher, JA, Mariño-Enríquez, A, Demetri, GD, Eilers, G, Czaplinski, JT, McKinley, A

Br. J. Cancer 2019
Participants
Input
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as an event of
Normal reaction
KIT binds type II TKIs (Homo sapiens)
Functional status

Loss of function of masitinib resistant KIT mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-04-01)
Reviewed
Pilco-Janeta, D  (2020-03-13)
Serrano, C  (2020-03-13)
García-Valverde, A  (2020-03-13)
Created
Rothfels, K  (2019-12-03)
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