Reactome | CST complex formation

CST complex formation

Stable Identifier

R-HSA-9668831

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
        
        Telomere C-strand synthesis initiation (Homo sapiens)
        
        CST complex formation (Homo sapiens)

General

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CTC1, STN1 and TEN1, orthologs of S. cerrevisiae proteins Cdc13, Stn1 and Ten1, respectively, form the CST complex. This evolutionarily conserved complex plays a role in telomere maintenance (Miyake et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19854130	RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway Nakamura, M, Ishikawa, F, Saito, M, Tamura, M, Shimamura, S, Miyake, Y, Nabetani, A, Yonehara, S	Mol. Cell	2009