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CTC1 [nucleoplasm]
Stable Identifier
R-HSA-9668825
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CST complex subunit CTC1, CTC1_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
Telomere C-strand synthesis initiation (Homo sapiens)
CST complex formation (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
CTC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q2NKJ3 CTC1
Gene Names
CTC1, C17orf68
Chain
chain:1-1217
Reference Genes
BioGPS Gene:80169 CTC1
COSMIC (genes):CTC1 CTC1
CTD Gene:80169 CTC1
dbSNP Gene:80169 CTC1
ENSEMBL:ENSG00000178971 CTC1
ENSEMBL_homo_sapiens_GENE:ENSG00000178971.17 CTC1
HGNC:26169 CTC1
KEGG Gene (Homo sapiens):80169 CTC1
Monarch:80169 CTC1
NCBI Gene:80169 CTC1
OMIM:613129 CTC1
UCSC:Q2NKJ3 CTC1
Reference Transcript
RefSeq:NM_025099.5 CTC1
Other Identifiers
11734894_at
11734895_at
16840915
16840919
219435_PM_at
219435_at
235523_PM_at
235523_at
2365947
2440873
2440883
2440896
2440913
2440928
2899289
2899522
2899524
2899922
2899924
2899936
2899937
2899938
2899960
2900004
2946775
2946785
2946801
3145300
3340842
3382577
3427071
3476784
3476791
3553102
3645737
3645747
3709523
3709525
3744307
3744308
3744309
3744310
3744311
3744312
3744313
3744315
3744317
3744319
3744320
3744321
3744323
3744325
3744326
3744327
3744328
3744329
3744330
3744331
3744332
3744333
3744334
3744335
3744337
3744340
3744342
3744343
3744344
3744345
3744346
3744347
3744348
3744349
3744350
3744353
3744354
3744355
3744357
3744358
3744359
3744360
3744361
3744362
3744363
3744364
3744365
3744367
3744368
3744369
3744370
3744372
3829241
59221_at
8012416
8012423
80169
88939_at
A_23_P78191
A_24_P390650
A_33_P3312104
GE83848
GE87315
GO:0000278
GO:0000723
GO:0000781
GO:0002376
GO:0003677
GO:0003697
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006260
GO:0006974
GO:0010389
GO:0010833
GO:0016233
GO:0030154
GO:0032200
GO:0032211
GO:0035264
GO:0042162
GO:0043226
GO:0045740
GO:0048146
GO:0048536
GO:0048538
GO:0048539
GO:0048856
GO:0051276
GO:0071425
GO:0090399
GO:0098505
GO:1990879
HMNXSV003040577
Hs.146114.0.A1_3p_at
Hs.156055.0.A1_3p_at
Hs.156055.0.A1_3p_x_at
ILMN_1702676
ILMN_1755711
ILMN_1772296
PH_hs_0022706
PH_hs_0037303
TC01001460.hg
TC01003430.hg
TC01003433.hg
TC01003436.hg
TC01003439.hg
TC01003442.hg
TC06000182.hg
TC06000197.hg
TC06000243.hg
TC06000244.hg
TC06000245.hg
TC06000246.hg
TC06000247.hg
TC06000259.hg
TC06001389.hg
TC06001393.hg
TC06001394.hg
TC08001445.hg
TC12000746.hg
TC12002101.hg
TC12002104.hg
TC14000779.hg
TC16000109.hg
TC17000134.hg
TC17001105.hg
TC17001110.hg
TC17001111.hg
TC17002477.hg
TC19000434.hg
g13376664_3p_at
Participates
as an input of
CST complex formation (Homo sapiens)
as a component of
CST complex [nucleoplasm] (Homo sapiens)
Inferred To
ctc1 [nucleoplasm]
(Danio rerio)
Ctc1 [nucleoplasm]
(Mus musculus)
Ctc1 [nucleoplasm]
(Rattus norvegicus)
CTC1 [nucleoplasm]
(Bos taurus)
CTC1 [nucleoplasm]
(Canis familiaris)
CTC1 [nucleoplasm]
(Dictyostelium discoideum)
CTC1 [nucleoplasm]
(Gallus gallus)
CTC1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_079375.3
OpenTargets
ENSG00000178971
GeneCards
Q2NKJ3
HPA
ENSG00000178971-CTC1
Ensembl
ENST00000449476
,
ENSG00000178971
,
ENSP00000498499
,
ENSP00000396018
,
ENST00000651323
PRO
Q2NKJ3
Pharos - Targets
Q2NKJ3
PDB
8D0B
,
8D0K
,
5W2L
,
6W6W
,
7U5C
,
8SOJ
,
8SOK
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.774
9
UniProt:Q86WV5 TEN1
1
TEN1 [nucleoplasm]
(R-HSA-9668823)
0.708
5
UniProt:Q92624 APBP2
0.556
3
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.527
2
UniProt:Q99615 DNAJC7
2
DNAJC7 [cytosol]
(R-HSA-5252099)
DNAJC7 [nucleoplasm]
(R-HSA-5255408)
0.527
2
UniProt:Q9UF02 CCG5
0.527
2
UniProt:Q9BRK4 LZTS2
0.527
2
UniProt:Q01664 TFAP4
0.527
2
UniProt:Q9Y2B0 CNPY2
0.527
2
UniProt:Q99435 NELL2
1
NELL2 [extracellular region]
(R-HSA-9010198)
0.527
2
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.527
2
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