NBEA (neurobeachin) binds to the regulatory subunit of PKA, PRKAR2A (PKA RIIalpha). This binding may be involved in localizing PKA to specific subcellular regions, e.g. postsynaptic density in neurons (Wang et al. 2000), but the experimental evidence is not conclusive. Mice that are heterozygous for NBEA gene knockout have NBEA haploinsufficiency and show aberrant PKA activity and changes in platelet morphology (Nuytens et al. 2013). PRKAR2A-binding domain of NBEA is not essential for NBEA-mediated targeting of glutamate and GABA receptors to the synapse (Farzana et al. 2016).
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