Reactome | IST1 [cytosol]

IST1 [cytosol]

Stable Identifier

R-HSA-9668516

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IST1 homolog, IST1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y6W3 CAPN7

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External Reference Information

External Reference

UniProt:P53990 IST1

Gene Names

IST1, KIAA0174

Chain

chain:1-364

Reference Genes

BioGPS Gene:9798 IST1

COSMIC (genes):IST1 IST1

CTD Gene:9798 IST1

dbSNP Gene:9798 IST1

ENSEMBL:ENSG00000182149 IST1

HGNC:28977 IST1

KEGG:hsa:9798 IST1

Monarch:9798 IST1

NCBI Gene:9798 IST1

OMIM:616434 IST1

UCSC:P53990 IST1

Reference Transcript

Participates

as an output of

VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)

as an input of

CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)

as a component of

LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)

Other forms of this molecule

IST1 [azurophil granule lumen]

IST1 [extracellular region]

Inferred To

ist1 [cytosol] (Danio rerio)

ist1 [cytosol] (Schizosaccharomyces pombe)

ist1 [cytosol] (Xenopus tropicalis)

IST1 [cytosol] (Bos taurus)

IST1 [cytosol] (Canis familiaris)

IST1 [cytosol] (Dictyostelium discoideum)

IST1 [cytosol] (Gallus gallus)

IST1 [cytosol] (Saccharomyces cerevisiae)

IST1 [cytosol] (Sus scrofa)

Ist1 [cytosol] (Drosophila melanogaster)

Ist1 [cytosol] (Mus musculus)

Ist1 [cytosol] (Rattus norvegicus)

istr-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001257904.1, NP_055576.2, NP_001257907.1, NP_001257905.1, NP_001257906.1, NP_001257908.1

OpenTargets

ENSG00000182149

ENSEMBL

ENSP00000438399, ENSP00000463711, ENST00000535424, ENSP00000475853, ENST00000538850, ENST00000378798, ENSP00000368075, ENST00000378799, ENSP00000368076, ENSP00000455860, ENST00000329908, ENSP00000457844, ENST00000541571, ENSP00000330408, ENSG00000182149, ENST00000544564, ENST00000606369

HPA

ENSG00000182149-IST1

GeneCards

IST1

PRO

P53990

Pharos - Targets

P53990

GlyGen

P53990

PDB

7S7J, 4U7I, 8UC6, 4U7E, 6TZ4, 3FRR, 6TZ5, 4U7Y, 6TZA, 4WZX, 3JC1, 8V2Q, 8V2S, 3FRS, 6E8G, 8V2R

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13798 APEH	3	APEH [cytosol] (R-HSA-5691510) APEH [extracellular region] (R-HSA-6806454) APEH [ficolin-1-rich granule lumen] (R-HSA-6801068)	0.749	5
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.684	6
UniProt:Q9Y2B5 VP9D1			0.564	2
UniProt:Q7Z479 Q7Z479			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q9UN37 VPS4A	1	VPS4A [cytosol] (R-HSA-917732)	0.527	2
UniProt:Q7LBR1 CHM1B			0.527	3
UniProt:Q9UBP0 SPAST	1	SPAST [cytosol] (R-HSA-9668426)	0.527	3
UniProt:P54253 ATX1			0.508	2

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