Reactome | IST1 [cytosol]

IST1 [cytosol]

Stable Identifier

R-HSA-9668516

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IST1 homolog, IST1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y6W3 CAPN7

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External Reference Information

External Reference

UniProt:P53990 IST1

Gene Names

IST1, KIAA0174

Chain

chain:1-364

Reference Genes

COSMIC (genes):IST1 IST1

dbSNP Gene:9798 IST1

ENSEMBL:ENSG00000182149 IST1

Participates

as an output of

VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)

as an input of

CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)

as a component of

LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)

Other forms of this molecule

IST1 [extracellular region]

IST1 [azurophil granule lumen]

Inferred To

ist1 [cytosol] (Danio rerio)

ist1 [cytosol] (Schizosaccharomyces pombe)

ist1 [cytosol] (Xenopus tropicalis)

IST1 [cytosol] (Bos taurus)

IST1 [cytosol] (Canis familiaris)

IST1 [cytosol] (Dictyostelium discoideum)

IST1 [cytosol] (Gallus gallus)

IST1 [cytosol] (Saccharomyces cerevisiae)

IST1 [cytosol] (Sus scrofa)

Ist1 [cytosol] (Drosophila melanogaster)

Ist1 [cytosol] (Mus musculus)

Ist1 [cytosol] (Rattus norvegicus)

istr-1 [cytosol] (Caenorhabditis elegans)

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13798 APEH	3	APEH [cytosol] (R-HSA-5691510) APEH [extracellular region] (R-HSA-6806454) APEH [ficolin-1-rich granule lumen] (R-HSA-6801068)	0.749	5
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.684	6
UniProt:Q9Y2B5 VP9D1			0.564	2
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q7Z479 Q7Z479			0.556	3
UniProt:Q9UN37 VPS4A	1	VPS4A [cytosol] (R-HSA-917732)	0.527	2
UniProt:P54253 ATX1			0.508	2

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