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NBEA binds DLG3
Stable Identifier
R-HSA-9668218
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
NBEA binds DLG3 (Homo sapiens)
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Based on studies in mouse brain and cultured mouse neurons, NBEA (neurobeachin) forms a complex with DLG3 (SAP-102) (Lauks et al. 2012, Farzana et al. 2016). The PH domain in the C-terminus of NBEA is involved in this interaction (Lauks et al. 2012). Based on UniProt reference protein sequence alignment, human NBEA protein is 97% identical with mouse Nbea, while human DLG3 protein is 95% identical with mouse Dlg3.
Participants
Input
DLG3 [plasma membrane]
(Homo sapiens)
NBEA [cytosol]
(Homo sapiens)
Output
NBEA:DLG3 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
Inferred From
Nbea binds Dlg3 (Mus musculus)
Authored
Orlic-Milacic, M (2019-11-22)
Reviewed
Miller, AC (2020-02-10)
Martin, EA (2020-02-10)
Created
Orlic-Milacic, M (2019-11-22)
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