ANKLE2 is deacetylated by SIRT2

Stable Identifier
R-HSA-9667952
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ANKLE2 (LEM4) is required for normal nuclear envelope (NE) formation at the end of mitosis (Ascencio et al. 2012, Kaufmann et al. 2016). Deacetylation of ANKLE2 on residue K302 by SIRT2 promotes this process (Kaufman et al. 2016).

Literature References
PubMed ID Title Journal Year
22770216 Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

Asencio, C, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Mall, M, Wallenfang, MR, Mattaj, IW, Gorjánácz, M

Cell 2012
27875273 SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation

Kaufmann, T, Kukolj, E, Brachner, A, Beltzung, E, Bruno, M, Kostrhon, S, Opravil, S, Hudecz, O, Mechtler, K, Warren, G, Slade, D

J. Cell. Sci. 2016
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD-dependent protein deacetylase activity of SIRT2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created