Reactome | ANKLE2 is deacetylated by SIRT2

ANKLE2 is deacetylated by SIRT2

Stable Identifier

R-HSA-9667952

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        ANKLE2 is deacetylated by SIRT2 (Homo sapiens)

General

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ANKLE2 (LEM4) is required for normal nuclear envelope (NE) formation at the end of mitosis (Ascencio et al. 2012, Kaufmann et al. 2016). Deacetylation of ANKLE2 on residue K302 by SIRT2 promotes this process (Kaufman et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
27875273	SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation Kostrhon, S, Kukolj, E, Opravil, S, Slade, D, Brachner, A, Kaufmann, T, Mechtler, K, Beltzung, E, Hudecz, O, Bruno, M, Warren, G	J. Cell. Sci.	2016
22770216	Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis Wallenfang, MR, Mall, M, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Asencio, C, Gorjánácz, M, Mattaj, IW	Cell	2012