KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region

Stable Identifier
R-HSA-9667809
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region
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Big potassium current channels (BK channels, tetramers of KCNMA1:KCNMB1) in outer hair cells (OHCs) open in response to an influx of calcium ions, thereby causing an efflux of potassium ions which hyperpolarizes the OHC and prevents the OHC from contracting (inferred from mouse homologs and rat homologs).

Participants
Input
Output
Participates
as an event of
Catalyst Activity

calcium-activated potassium channel activity of KCNMA1:KCNMB1 [plasma membrane]

Physical Entity
KCNMA1:KCNMB1 [plasma membrane] (Homo sapiens)
Activity
calcium-activated potassium channel activity (GO:0015269)
This event is regulated
Positively by
Regulator
Ca2+ [cytosol]
Inferred From
Kcnma1:Kcnmb1 transports potassium ions from the cytosol to the extracellular region (Rattus norvegicus)
Kcnma1:Kcnmb1 transport potassium ions from the cytosol to the extracellular region (Mus musculus)
Cross References
Rhea
Authored
May, B  (2019-11-16)
Reviewed
Dallos, P  (2020-09-14)
Furness, DN  (2020-09-14)
Created
May, B  (2019-11-17)
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