ERBB2 T733I does not bind tesevatinib

Stable Identifier
R-HSA-9665315
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following ERBB2 KD mutants are resistant to tesevatinib (EXEL-7647):
ERBB2 T733I (Trowe et al. 2008);

Literature References
PubMed ID Title Journal Year
18413839 EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation

Trowe, T, Boukouvala, S, Calkins, K, Cutler, RE, Fong, R, Funke, R, Gendreau, SB, Kim, YD, Miller, N, Woolfrey, JR, Vysotskaia, V, Yang, JP, Gerritsen, ME, Matthews, DJ, Lamb, P, Heuer, TS

Clin. Cancer Res. 2008
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
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