Resistant ERBB2 KD mutants do not bind neratinib

Stable Identifier
R-HSA-9665286
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following ERBB2 KD mutants are resistant to neratinib (HKI-272):
ERBB2 T798I (Hanker et al. 2017);
ERBB2 T798M (Hanker et al. 2017);

Literature References
PubMed ID Title Journal Year
28274957 An Acquired HER2T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer

Hanker, AB, Brewer, MR, Sheehan, JH, Koch, JP, Sliwoski, GR, Nagy, R, Lanman, R, Berger, MF, Hyman, DM, Solit, DB, He, J, Miller, V, Cutler, RE, Lalani, AS, Cross, D, Lovly, CM, Meiler, J, Arteaga, CL

Cancer Discov 2017
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created