Resistant ERBB2 KD mutants do not bind AEE788

Stable Identifier
R-HSA-9665278
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The following ERBB2 KD mutants are resistant to AEE788:
ERBB2 L755P (Kancha et al. 2011);
ERBB2 L755S (Kancha et al. 2011);
ERBB2 V777L (Kancha et al. 2011);
ERBB2 T798M (Kancha et al. 2011);
ERBB2 T862A (Kancha et al. 2011);
Literature References
PubMed ID Title Journal Year
22046346 Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib

Duyster, J, Kancha, RK, Engh, RA, Peschel, C, Bartosch, N, von Bubnoff, N

PLoS ONE 2011
Participants
Participates
Normal reaction
Functional status

Loss of function of ERBB2 KD mutants (AEE788 resistant):ERBIN:HSP90:CDC37 [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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Reviewed
Created
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