Resistant ERBB2 KD mutants do not bind AEE788

Stable Identifier
R-HSA-9665278
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Resistant ERBB2 KD mutants do not bind AEE788
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The following ERBB2 KD mutants are resistant to AEE788:
ERBB2 L755P (Kancha et al. 2011);
ERBB2 L755S (Kancha et al. 2011);
ERBB2 V777L (Kancha et al. 2011);
ERBB2 T798M (Kancha et al. 2011);
ERBB2 T862A (Kancha et al. 2011);
Literature References
PubMed ID Title Journal Year
22046346 Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib

Kancha, RK, von Bubnoff, N, Bartosch, N, Peschel, C, Engh, RA, Duyster, J

PLoS ONE 2011
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Normal reaction
ERBB2 binds TKIs (Homo sapiens)
Functional status

Loss of function of ERBB2 KD mutants (AEE788 resistant):ERBIN:HSP90:CDC37 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2019-10-30)
Reviewed
Kancha, RK  (2019-09-16)
Created
Orlic-Milacic, M  (2019-10-30)
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