Resistant ERBB2 KD mutants do not bind AEE788

Stable Identifier
R-HSA-9665278
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following ERBB2 KD mutants are resistant to AEE788:
ERBB2 L755P (Kancha et al. 2011);
ERBB2 L755S (Kancha et al. 2011);
ERBB2 V777L (Kancha et al. 2011);
ERBB2 T798M (Kancha et al. 2011);
ERBB2 T862A (Kancha et al. 2011);

Literature References
PubMed ID Title Journal Year
22046346 Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib

Kancha, RK, von Bubnoff, N, Bartosch, N, Peschel, C, Engh, RA, Duyster, J

PLoS ONE 2011
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
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