Reactome | ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5

ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5

Stable Identifier

R-HSA-9664888

Type

Reaction [binding]

Species

Homo sapiens

Compartment

peroxisomal membrane

ReviewStatus

5/5

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SVG | | PPTX | SBGN

ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5

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Phosphorylation of Peroxisomal targeting signal 1 receptor protein (PEX5) at Ser141 promotes the ubiquitination of PEX5. The RING peroxins complex composed of: Peroxisome biogenesis factor 2 (PEX2), Peroxisome biogenesis factor 10 (PEX10), and Peroxisome assembly protein 12 (PEX12) form part of a peroxisome localized E3 ligase that ubiquitinates PEX5 at Lys209 (Zhang J et al. 2015). This mono ubiquitination of PEX5 helps to recruit the autophagy machinery to the peroxisome.

Literature References

PubMed ID	Title	Journal	Year
26344566	ATM functions at the peroxisome to induce pexophagy in response to ROS Kim, J, Walker, CL, Pandita, TK, Charaka, VK, Jing, J, Dere, R, Zhang, J, Kastan, MB, Lee, JH, Alexander, A, Pandita, RK, Paull, TT, Tripathi, DN, Powell, RT, Tait-Mulder, J	Nat. Cell Biol.	2015