ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5

Stable Identifier
R-HSA-9664888
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal membrane
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ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
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Phosphorylation of Peroxisomal targeting signal 1 receptor protein (PEX5) at Ser141 promotes the ubiquitination of PEX5. The RING peroxins complex composed of: Peroxisome biogenesis factor 2 (PEX2), Peroxisome biogenesis factor 10 (PEX10), and Peroxisome assembly protein 12 (PEX12) form part of a peroxisome localized E3 ligase that ubiquitinates PEX5 at Lys209 (Zhang J et al. 2015). This mono ubiquitination of PEX5 helps to recruit the autophagy machinery to the peroxisome.

Literature References
PubMed ID Title Journal Year
26344566 ATM functions at the peroxisome to induce pexophagy in response to ROS

Zhang, J, Tripathi, DN, Jing, J, Alexander, A, Kim, J, Powell, RT, Dere, R, Tait-Mulder, J, Lee, JH, Paull, TT, Pandita, RK, Charaka, VK, Pandita, TK, Kastan, MB, Walker, CL

Nat. Cell Biol. 2015
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Orthologous Events
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Canis familiaris)
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Danio rerio)
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Gallus gallus)
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Mus musculus)
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Sus scrofa)
Authored
Varusai, TM  (2019-10-29)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2019-10-28)
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