MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1

Stable Identifier
R-HSA-9664880
Type
Reaction [binding]
Species
Homo sapiens
Compartment
peroxisomal membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Autophagic receptors, Next to BRCA1 gene 1 protein (NBR1) and Sequestosome 1 (SQSTM1) cooperate to bind and recruit ubiquitinated peroxisomes to the autophagy machinery. NBR1 and SQSTM1 have similar protein domain architecture and bind to Microtubule associated proteins 1A/1B light chain 3B (MAP1LC3B)/LC3 via an LC3 interacting region (LIR) (Kirkin V et al. 2009). Subsequently, peroxisomes are engulfed within the autophagosome and degraded.

Literature References
PubMed ID Title Journal Year
19398892 NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets

Kirkin, V, Lamark, T, Johansen, T, Dikic, I

Autophagy 2009
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Bos taurus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Caenorhabditis elegans)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Canis familiaris)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Danio rerio)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Dictyostelium discoideum)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Gallus gallus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Mus musculus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Rattus norvegicus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Schizosaccharomyces pombe)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Sus scrofa)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Xenopus tropicalis)
Authored
Varusai, TM  (2019-10-29)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2019-10-28)