LTC4-CYSLTR mediated IL4 production

Stable Identifier
R-HSA-9664535
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
LTC4-CYSLTR mediated IL4 production
Click the image above or here to open this pathway in the Pathway Browser

The Leukotriene C4 (LTC4) is a metabolite of arachidonic acid that can be produced intracellularly or extracellularly. LTC4 binds an unidentified, intracellular cysLTR. Signalling downstream LTC4 cysLTR binding has been associated with the production of IL4, independent of the GPCR associated heterotrimeric protein Gq (Bandeira Melo et al. 2002).

Literature References
PubMed ID Title Journal Year
12235216 Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion

Bandeira-Melo, C, Woods, LJ, Phoofolo, M, Weller, PF

J. Exp. Med. 2002
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
negative regulation of inflammatory response to antigenic stimulus (0002862)
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Jassal, B  (2020-01-07)
Murillo, JI  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-25)
Cite Us!