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LTC4-CYSLTR mediated IL4 production
Stable Identifier
R-HSA-9664535
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
LTC4-CYSLTR mediated IL4 production (Homo sapiens)
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The Leukotriene C4 (LTC4) is a metabolite of arachidonic acid that can be produced intracellularly or extracellularly. LTC4 binds an unidentified, intracellular cysLTR. Signalling downstream LTC4 cysLTR binding has been associated with the production of IL4, independent of the GPCR associated heterotrimeric protein Gq (Bandeira Melo et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
12235216
Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion
Weller, PF
,
Phoofolo, M
,
Bandeira-Melo, C
,
Woods, LJ
J. Exp. Med.
2002
Participants
Events
GGT1, 5 dimers hydrolyse LTC4 to LTD4
(Homo sapiens)
LTD4 is converted to LTE4 by DPEP1/2
(Homo sapiens)
LTC4 binds CyslTR1,2
(Homo sapiens)
Participates
as an event of
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
Event Information
Go Biological Process
negative regulation of inflammatory response to antigenic stimulus (0002862)
Disease
Name
Identifier
Synonyms
cutaneous leishmaniasis
DOID:9111
Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Murillo, JI (2020-01-07)
Jassal, B (2020-01-07)
Reviewed
Gregory, DJ (2020-02-04)
Created
Murillo, JI (2019-10-25)
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