Leishmania parasites are dimorphic protozoa, being extracellular and flagellated (promastigotes) in the vector insect, and intracellular and aflagellated (amastigotes) in the host. While the vector fly feeds on the blood of the host, it transmits the promastigotes which are subsequently phagocytosed. The transition to the non motile form occurs within the phagosomal pathway; this process requires the delay of the maturation of the phagosome in such a way that the pH conditions are not harmful to the promastigote. Once it is in the amastigote form, maturation of the parasitophorous vacuole continues (Martínez López et al. 2018).