LTC4 binds CyslTR1,2

Stable Identifier
Reaction [binding]
Homo sapiens
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The cysteinyl-leukotrienes (cys-LTs) are potent smooth muscle contractile agents mediating bronchoconstriction. Examples are LTC4, LTD4 and LTE4. There are two human cys-LT receptors, 1 (Lynch KR et al, 1999) and 2 (Heise CE et al, 2000). They mediate their effects via coupling to the G protein alpha q/11 subunit (Sarau HM et al, 1999). However, signalling downstream LTC4-cysLTR binding has been associated with the production of IL4, independent of the GPCR associated heterotrimeric protein Gq (Bandeira Melo et al. 2002).

Literature References
PubMed ID Title Journal Year
10462554 Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor

Jenkins, O, Muir, AI, Nuthulaganti, P, Chambers, J, Sarau, HM, Bergsma, DJ, Herrity, NC, Buckley, PT, Muccitelli, RM, Dytko, GM, Elshourbagy, N, Wilson, S, Halsey, W, Murdock, PR, Sathe, G, Ames, RS, Hay, DW, Foley, JJ, Schmidt, DB, Ellis, C

Mol Pharmacol 1999
12235216 Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion

Weller, PF, Phoofolo, M, Bandeira-Melo, C, Woods, LJ

J. Exp. Med. 2002
10851239 Characterization of the human cysteinyl leukotriene 2 receptor

Zeng, Z, Liu, Y, Sawyer, N, Ma, L, O'Dowd, BF, Figueroa, DJ, Bellefeuille, JN, Im, DS, Austin, CP, Metters, KM, Evans, JF, Nguyen, T, George, SR, Williams DL, Jr, Stocco, R, Abramovitz, M, Clements, MK, Lynch, KR, Liu, Q, Cheng, R, Coulombe, N, Heise, CE, O'Neill, GP

J Biol Chem 2000
10391245 Characterization of the human cysteinyl leukotriene CysLT1 receptor

Hooks, SB, Zeng, Z, Bai, C, Sawyer, N, Connolly, BM, Caskey, CT, Figueroa, DJ, Im, DS, Austin, CP, Ford-Hutchinson, AW, Metters, KM, Evans, JF, Chateauneuf, A, Williams DL, Jr, Stocco, R, Hosfield, E, Kargman, S, Greig, GM, Abramovitz, M, Liu, Q, Lynch, KR, Coulombe, N, O'Neill, GP

Nature 1999
This event is regulated