LTC4 binds CyslTR1,2

Stable Identifier
R-HSA-9664306
Type
Reaction [binding]
Species
Homo sapiens
Compartment
external side of plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
LTC4 binds CyslTR1,2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The cysteinyl-leukotrienes (cys-LTs) are potent smooth muscle contractile agents mediating bronchoconstriction. Examples are LTC4, LTD4 and LTE4. There are two human cys-LT receptors, 1 (Lynch KR et al, 1999) and 2 (Heise CE et al, 2000). They mediate their effects via coupling to the G protein alpha q/11 subunit (Sarau HM et al, 1999). However, signalling downstream LTC4-cysLTR binding has been associated with the production of IL4, independent of the GPCR associated heterotrimeric protein Gq (Bandeira Melo et al. 2002).
Literature References
PubMed ID Title Journal Year
10462554 Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor

Sarau, HM, Ames, RS, Chambers, J, Ellis, C, Elshourbagy, N, Foley, JJ, Schmidt, DB, Muccitelli, RM, Jenkins, O, Murdock, PR, Herrity, NC, Halsey, W, Sathe, G, Muir, AI, Nuthulaganti, P, Dytko, GM, Buckley, PT, Wilson, S, Bergsma, DJ, Hay, DW

Mol Pharmacol 1999
12235216 Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion

Bandeira-Melo, C, Woods, LJ, Phoofolo, M, Weller, PF

J. Exp. Med. 2002
10851239 Characterization of the human cysteinyl leukotriene 2 receptor

Heise, CE, O'Dowd, BF, Figueroa, DJ, Sawyer, N, Nguyen, T, Im, DS, Stocco, R, Bellefeuille, JN, Abramovitz, M, Cheng, R, Williams DL, Jr, Zeng, Z, Liu, Q, Ma, L, Clements, MK, Coulombe, N, Liu, Y, Austin, CP, George, SR, O'Neill, GP, Metters, KM, Lynch, KR, Evans, JF

J Biol Chem 2000
10391245 Characterization of the human cysteinyl leukotriene CysLT1 receptor

Lynch, KR, O'Neill, GP, Liu, Q, Im, DS, Sawyer, N, Metters, KM, Coulombe, N, Abramovitz, M, Figueroa, DJ, Zeng, Z, Connolly, BM, Bai, C, Austin, CP, Chateauneuf, A, Stocco, R, Greig, GM, Kargman, S, Hooks, SB, Hosfield, E, Williams DL, Jr, Ford-Hutchinson, AW, Caskey, CT, Evans, JF

Nature 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
GGT1 dimer [plasma membrane] (Homo sapiens)
Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-22)
Cite Us!