Opsonized leishmania amastigote binds FCGR3

Stable Identifier
R-HSA-9664268
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
plasma membrane
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Opsonized leishmania amastigote binds FCGR3
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Leishmania amastigotes parasites opsonized by IgG are more susceptible to be phagocytosed through FcγRs. Nevertheless, besides the phagocytosis induction, the interaction IgG-FcγRs has been implicated in the synthesis induction, of several cytokines (Buxbaum 2013; Chu et al. 2010; Thomas and Buxbaum 2008). In particular, Buxbaum et al. in 2008 showed that IgGs bound glycoinositol phospholipids (GIPLs) of L. Mexicana and that IgG:GIPLs induces the synthesis of IL-10 through FcγRIII.

Literature References
Participants
Input
Output
Participant Of
hasEvent
Disease
Name Identifier Synonyms
cutaneous leishmaniasis 9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-22)