Leishmania amastigotes parasites opsonized by IgG are more susceptible to be phagocytosed through FcγRs. Nevertheless, besides the phagocytosis induction, the interaction IgG-FcγRs has been implicated in the synthesis induction, of several cytokines (Buxbaum 2013; Chu et al. 2010; Thomas and Buxbaum 2008). In particular, Buxbaum et al. in 2008 showed that IgGs bound glycoinositol phospholipids (GIPLs) of L. Mexicana and that IgG:GIPLs induces the synthesis of IL-10 through FcγRIII.