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Opsonized leishmania amastigote binds FCGR3
Stable Identifier
R-HSA-9664268
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
plasma membrane
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
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Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
Opsonized leishmania amastigote binds FCGR3 (Homo sapiens)
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Leishmania amastigotes parasites opsonized by IgG are more susceptible to be phagocytosed through FcγRs. Nevertheless, besides the phagocytosis induction, the interaction IgG-FcγRs has been implicated in the synthesis induction, of several cytokines (Buxbaum 2013; Chu et al. 2010; Thomas and Buxbaum 2008). In particular, Buxbaum et al. in 2008 showed that IgGs bound glycoinositol phospholipids (GIPLs) of L. Mexicana and that IgG:GIPLs induces the synthesis of IL-10 through FcγRIII.
Literature References
PubMed ID
Title
Journal
Year
18070890
FcgammaRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions
Thomas, BN
,
Buxbaum, LU
Infect. Immun.
2008
23675550
Leishmania mexicana infection induces IgG to parasite surface glycoinositol phospholipids that can induce IL-10 in mice and humans
Buxbaum, LU
PLoS Negl Trop Dis
2013
21037092
IgG1 is pathogenic in Leishmania mexicana infection
Thomas, BN
,
Chu, N
,
Patel, SR
,
Buxbaum, LU
J. Immunol.
2010
Participants
Input
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane]
(Homo sapiens)
IgG:Lma antigens [plasma membrane]
(Homo sapiens)
Output
IgG:Lma antigens:FCGR3A:CD3 dimers [plasma membrane]
(Homo sapiens)
Participates
as an event of
FCGR3A-mediated IL10 synthesis (Homo sapiens)
Disease
Name
Identifier
Synonyms
cutaneous leishmaniasis
DOID:9111
Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Murillo, JI (2020-01-07)
Jassal, B (2020-01-07)
Reviewed
Gregory, DJ (2020-02-04)
Created
Murillo, JI (2019-10-22)
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