Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Selective autophagy
Stable Identifier
R-HSA-9663891
Type
Pathway
Species
Homo sapiens
Compartment
autophagosome
,
autophagosome membrane
,
cytosol
,
lysosomal lumen
,
lysosomal membrane
,
phagocytic vesicle
,
phagocytic vesicle membrane
,
phagophore assembly site membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
Click the image above or
here
to open this pathway in the Pathway Browser
Autophagy can be a selective process where specific cargo (organelles/proteins) are targetted to degradation in the lysosome. In general, selective autophagy is initiated when a cellular signal tags the cargo organelle for degradation. Subsequently, cargo recognition proteins detect and recruit the organelle to interact directly or indirectly with Atg proteins forming the phagophore. The next steps involve formation of the autophagosome and fusion with the lysosome for degradation. Depending upon the organelle, different molecules are used to for the autophagy mechanism (Andling AL et al. 2017). Consequently, the different mechanisms are known by the organelle degraded such as mitophagy for mitochondia, lipophagy for lipid droplets, pexophagy for peroxisomes and aggrephagy for aggregated proteins.
Literature References
PubMed ID
Title
Journal
Year
28399394
Cleaning House: Selective Autophagy of Organelles
Anding, AL
,
Baehrecke, EH
Dev. Cell
2017
Participants
Events
Mitophagy
(Homo sapiens)
Aggrephagy
(Homo sapiens)
Lipophagy
(Homo sapiens)
Pexophagy
(Homo sapiens)
Participates
as an event of
Macroautophagy (Homo sapiens)
Event Information
Go Biological Process
macroautophagy (0016236)
Orthologous Events
Selective autophagy (Bos taurus)
Selective autophagy (Caenorhabditis elegans)
Selective autophagy (Canis familiaris)
Selective autophagy (Danio rerio)
Selective autophagy (Dictyostelium discoideum)
Selective autophagy (Drosophila melanogaster)
Selective autophagy (Gallus gallus)
Selective autophagy (Mus musculus)
Selective autophagy (Plasmodium falciparum)
Selective autophagy (Rattus norvegicus)
Selective autophagy (Saccharomyces cerevisiae)
Selective autophagy (Schizosaccharomyces pombe)
Selective autophagy (Sus scrofa)
Selective autophagy (Xenopus tropicalis)
Authored
Varusai, TM (2019-11-08)
Created
Varusai, TM (2019-10-17)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text