KCNN2 transports K+ from the cytosol to the extracellular region

Stable Identifier
R-HSA-9663752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
KCNN2 transports K+ from the cytosol to the extracellular region
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Small potassium current channels (SK2 channels, KCNN2 tetramers) in outer hair cells (OHCs) open in response to cytosolic calcium and transport potassium ions from the cytosol to the extracellular region, resulting in hyperpolarization and inhibition of contraction of the OHC (inferred from the mouse homolog).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

calcium-activated potassium channel activity of KCNN2 tetramer [plasma membrane]

Physical Entity
KCNN2 tetramer [plasma membrane] (Homo sapiens)
Activity
calcium-activated potassium channel activity (GO:0015269)
Inferred From
Kcnn2 transports K+ from the cytosol to the extracellular region (Mus musculus)
Cross References
Rhea
Authored
May, B  (2019-10-08)
Reviewed
Dallos, P  (2020-09-14)
Furness, DN  (2020-09-14)
Created
May, B  (2019-10-12)
Cite Us!