Reactome | BIL dissociates from GSTA1, FABP1

BIL dissociates from GSTA1, FABP1

Stable Identifier

R-HSA-9663492

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Once GSTA1 and FABP1 proteins transport bilirubin to the ER, it is assumed they must dissociate from BIL ((Levi et al. 1969, Simons & Jagt 1980) to allow its translocation, most likely by simple diffusion, into the ER lumen.

Literature References

PubMed ID	Title	Journal	Year
4980931	Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions Gatmaitan, Z, Levi, AJ, Arias, IM	J. Clin. Invest.	1969
7372607	Bilirubin binding to human liver ligandin (glutathione S-transferase) Simons, PC, Jagt, DL	J. Biol. Chem.	1980