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SLC26A5 (prestin) changes conformation in response to depolarization
Stable Identifier
R-HSA-9663354
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
SLC26A5 (prestin) changes conformation in response to depolarization (Homo sapiens)
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The membrane protein SLC26A5 (prestin) contracts in the plane of the membrane in response to depolarization of the cell caused by opening of the mechanoelectric transduction (MET) channel (inferred from rat homologs). Likewise, SLC26A5 expands in the plane of the membrane in response to hyperpolarization caused by MET channel closing. A current model for the reaction posits that the association of anions (chloride or bicarbonate) with a binding pocket midway along the permeation pathway within SLC26A5 causes a change in the area occupied by SLC26A5 in the membrane (inferred from the rat homolog). An influx of cations through the MET channel causes dissociation of anions from SLC26A5, reversing the conformational change. The contraction-elongation cycle of OHCs, due to conformational changes of prestin, provides feedback-amplification of the motions (principally the reticular lamina) of the organ of Corti. At low sound levels the amplification is about a 1000-fold, decreasing nonlinearly as sound level increases. In the absence of either OHCs (Ryan and Dallos 1975) or functional prestin (inferred from mouse homologs) the amplification disappears.
Literature References
PubMed ID
Title
Journal
Year
10821263
Prestin is the motor protein of cochlear outer hair cells
Shen, W
,
Dallos, P
,
Madison, LD
,
Zheng, J
,
Long, KB
,
He, DZ
Nature
2000
Participants
Input
SLC26A5 tetramer (expanded):Cl-,HCO3- [plasma membrane]
(Homo sapiens)
Output
Cl-,HCO3- [cytosol]
SLC26A5 tetramer [plasma membrane]
(Homo sapiens)
Participates
as an event of
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
This event is regulated
Positively by
Regulator
K+ [cytosol]
Inferred From
Slc26a5 changes conformation in response to depolarization (Rattus norvegicus)
Slc26a5 changes conformation in response to depolarization (Mus musculus)
Authored
May, B (2019-09-30)
Reviewed
Dallos, P (2020-09-14)
Furness, DN (2020-09-14)
Created
May, B (2019-09-30)
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