p-S,T-ADAM17(215-827):Zn2+ cleaves CD163

Stable Identifier
R-HSA-9662837
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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p-S,T-ADAM17(215-827):Zn2+ cleaves CD163
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The scavenger receptor cysteine-rich type 1 (CD163) is a transmembrane macrophage protein which upon cleavage, leads to the release of a soluble form (sCD163, CD163(42-1050)) (Droste, Sorg, and Högger 1999 and Hintz et al. 2002). The inflammation-responsive protease ADAM17 can mediate the cleavage of CD163 to release sCD163 (Etzerodt et al. 2010 & Etzerodt et al. 2014).
Literature References
PubMed ID Title Journal Year
24275664 Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages

Etzerodt, A, Rasmussen, MR, Svendsen, P, Chalaris, A, Schwarz, J, Galea, I, Møller, HJ, Moestrup, SK

J. Biol. Chem. 2014
10066432 Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family

Droste, A, Sorg, C, Högger, P

Biochem. Biophys. Res. Commun. 1999
20807704 Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163

Etzerodt, A, Maniecki, MB, Møller, K, Møller, HJ, Moestrup, SK

J. Leukoc. Biol. 2010
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Output
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Catalyst Activity

metallopeptidase activity of p-S,T-ADAM17(215-827):Zn2+ [plasma membrane]

Physical Entity
p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Homo sapiens)
Activity
metallopeptidase activity (GO:0008237)
Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-09-24)
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