PLK2, MAPK14 phosphorylate ADAM17

Stable Identifier
R-HSA-9662823
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The phosphorylation of disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) by PLK2 and MAPKs has been determined by direct and indirect experiments (Müllberg et al. 1993, Schwarz et al. 2014, Fan and Derynck 1999; Gechtman et al. 1999; Díaz-Rodríguez et al. 2002; Fan, Turck, and Derynck 2003 & Xu and Derynck 2010). Specifically, the phosphorylation at residues Thr735 (Díaz-Rodríguez et al. 2002 & Xu and Derynck 2010) and Ser819 is required for ectodomains shedding.

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Catalyst Activity
Title
protein serine/threonine kinase activity of PLK2, MAPK14 [cytosol]
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Activity
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